Advances in pharmacological effects of higenamine on cardiovascular system
10.16438/j.0513-4870.2019-0683
- VernacularTitle:去甲乌药碱对心血管药理作用的研究进展
- Author:
Yu-hong WANG
1
;
Cong LI
1
;
Shuang JIANG
1
;
Jian-dong JIANG
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
higenamine;
cardiotonic action;
vasodilation;
anti-oxidative;
anti-apoptotic;
anti-platelet aggregation
- From:
Acta Pharmaceutica Sinica
2020;55(3):392-397
- CountryChina
- Language:Chinese
-
Abstract:
Higenamine (HG) is an active cardiotonic component isolated from Aconite. Chinese and foreign scholars have done a lot of research on the metabolism and pharmacological effects of HG, which confirmed that it has cardiovascular pharmacological effects of cardiactonic action and vasodilation for the treatment of heart failure and bradycardia, anti-oxidative and anti-apoptotic effects which can be used to protect the heart and reduce heart ischemia and reperfusion injury. In addition, HG inhibits the expression of iNOS mRNA by inhibiting the activity of the transcription factor NF-κB, inhibits the lipopolysaccharide (LPS)-induced NO product, and inhibits platelet aggregation and thrombus formation, thereby improving the experimental septic shock in animals. This article reviews the recent progress in cardiovasular pharmacology of HG, which will contribute to the further development and clinical application of it in the future.
