Menopausal hormone therapy on breast lesions in perimenopausal women
10.19485/j.cnki.issn2096-5087.2019.09.005
- VernacularTitle:激素治疗干预对围绝经期女性乳腺病变的影响
- Author:
Lin MA
1
,
2
;
Jian HUANG
;
Linjie CHEN
;
Xiangming LOU
;
Jian ZHOU
;
Jianyu XIA
;
Chenlei LU
;
Hongyan WU
;
Zhifen ZHANG
Author Information
1. Department of Gynecology,Hangzhou Women'
2. s Hospital
- Publication Type:Journal Article
- Keywords:
Peri-menopause，Menopausal hormone therapy，Breast density，Breast calcification，Breast fibrous tissue volume
- From:
Journal of Preventive Medicine
2019;31(9):882-885
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between menopausal hormone therapy（MHT）and breast lesions in perimenopausal women,and to provide evidence for safe use of MHT.
Methods:The 40-60 year-old women who visited Hangzhou Women's Hospital and met the diagnostic criteria for perimenopausal syndrome were recruited. The intervention group received MHT and was divided into three subgroups according to the MHT regimen：estrogen-progesterone cycle therapy（A）,estrogen-progesterone continuous therapy（B）,estrogen therapy（C）. The control group did not receive MHT. All the patients received regular mammography to quantify and evaluate breast lesions. The generalized estimating equation was used to analyze the changes of breast lesions between different groups.
Results:There were 80 cases in the intervention group,with 49 in group A,26 in group B,5 in group C,and 80 cases in the control group. After two years of follow-up,there was no statistically significant differences of time,group and interaction in breast density,volume of breast fibrous tissue and the volume of breast between three intervention groups and the control group（P>0.05）; there was no statistically significant differences of group and interaction in positive rate of calcification and breast mass between the intervention group and the control group（P>0.05）.
Conclusion:Receiving MHT intervention for two years did not increase the risk of breast lesions.
- Full text:激素治疗干预对围绝经期女性乳腺病变的影响.pdf
