Effects of cassia seed,red yeast rice,ginkgo biloba leaf and salvia miltiorrhiza compounds on blood lipid level of rats
10.19485/j.cnki.issn2096-5087.2019.02.006
- VernacularTitle:决明子、红曲、银杏叶和丹参复合物对大鼠血脂水平的影响
- Author:
Meitong LIU
1
;
Luwei CUI
;
Zimin LI
;
Yuming HU
Author Information
1. Hunan Provincial Center for Disease Control and Prevention
- Publication Type:Journal Article
- Keywords:
Cassia seed，Red yeast rice，Ginkgo biloba leaf，Salvia miltiorrhiza，Blood lipid，Hyperlipidemia
- From:
Journal of Preventive Medicine
2019;31(2):132-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To learn the effects of cassia seed extract,ginkgo biloba leaf extract,salvia miltiorrhiza extract and red yeast rice compounds on blood lipid level of rats with hyperlipidemia.
Methods :The model of hyperlipidemia in SD rats was established. The rats in the low,moderate and high dose groups were given 0.267 g/kg body weight,0.533 g/kg body weight and 1.600 g/kg body weight of cassia seed,red yeast rice,ginkgo biloba leaf and salvia miltiorrhiza compounds by gavage for 30 days. A blank control group and a model control group were also set. The levels of serum total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）and low-density lipoprotein cholesterol（LDL-C）in the five groups were measured before and after the intragastric administration.
Results :One week after the model was founded,the levels of serum TC,TG and LDL-C in the model control group were higher than those in the blank control group（P<0.05）. Before the intragastric administration,there were no significant differences in the levels of serum TC,TG,HDL-C and LDL-C between the model control group and each dosage group（P>0.05）. After the intragastric administration,there were no significant differences in the levels of serum HDL-C and LDL-C between the model control group and each dosage group（P>0.05）. The levels of serum TC and TG in the high dose group were significantly lower than those in the model control group（P<0.05）;There was no significant differences in the levels of serum TC and TG between the moderate dose,low dose group and the model control group（P>0.05）.
Conclusion: The compounds of cassia seed extract,red yeast rice,ginkgo biloba extract and salvia miltiorrhiza extract with a dosage of 1.600 g/kg body weight can reduce serum TC and TG levels in rats with hyperlipidemia.
- Full text:决明子、红曲、银杏叶和丹参复合物对大鼠血脂水平的影响.pdf
