Mycophenolate Mofetil Versus Azathioprine in Cyclosporine Based Triple Immunosuppression.
- Author:
Seung Cheol KIM
1
;
Duck Jong HAN
;
Tae Hee KIM
;
Song Cheol KIM
Author Information
1. Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Renal transplant;
Mycophenolate mofetil (MMF);
Azathioprine (AZA);
Rejection
- MeSH:
Allografts;
Azathioprine*;
Cyclosporine*;
Diarrhea;
Follow-Up Studies;
Graft Survival;
Humans;
Immunosuppression*;
Kidney Transplantation;
Leukopenia;
Retrospective Studies;
Tissue Donors;
Transplantation
- From:The Journal of the Korean Society for Transplantation
2002;16(1):70-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Recent studies have demonstrated improved outcome in renal transplant recipients treated with mycophenolate mofetil (MMF). We compared the outcome of allograft treated with MMF versus AZA in CsA/prednisolone based immunosuppressant treated renal transplant at our center. METHODS: We retrospectively reviewed allograft recipients who had been transplanted from Jan. to Dec. 1998 in AZA group (n=87) and Jan. to Dec. 1999 in MMF group (n=99). The variables of donor and recipient as well as the survival factors were compared between the two groups. And the adverse effects of MMF and AZA were analyzed. Duration of follow-up was one year, respectively. RESULTS: Between the two groups, there were no significant differences in sex, age, type of donor, ABO and HLA mismatches. Patients treated with MMF and CsA had significantly fewer episodes of rejection; 5/99 (5.1%) in MMF versus 13/87 (14.9%) in AZA (P<0.05). In the MMF group, patients with higher dose (1.5 g/d) had lower rejection rate than those with lower dose, illustrating the dose dependant immunosuppressive effect. However one-year allograft survival did not show any significant difference between two groups (96.9% in MMF versus 97.7% in AZA). Gastrointestinal symptoms such as diarrhea were more common in MMF group but hepatotoxicity and leukopenia were more prevalent in AZA group. CONCLUSION: While the one-year graft survival following renal transplantation was similar between the MMF and AZA group, lower rejection rate in MMF group suggests the favorable long term graft survival with MMF.
