Comparison of Tacrolimus and Cyclosporine in Kidney Transplantation.
- Author:
Eun Ah HWANG
1
;
Jung Hoon SUNG
;
Min Kyung KANG
;
Seung Yup HAN
;
Sung Bae PARK
;
Hyun Chul KIM
Author Information
1. Dongsan Kidney Institute, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. k780121@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Kidney transplantation;
Tacrolimus;
Cyclosporine;
Survival;
Side effect
- MeSH:
Abdominal Pain;
Calcineurin;
Cyclosporine*;
Gingiva;
Graft Survival;
Headache;
Humans;
Hyperkalemia;
Hyperplasia;
Hypertension;
Immunosuppression;
Incidence;
Kidney Transplantation*;
Kidney*;
Retrospective Studies;
Survival Rate;
Tacrolimus*;
Transplantation;
Transplants;
Tremor
- From:The Journal of the Korean Society for Transplantation
2002;16(1):84-89
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The calcineurin inhibitors, tacrolimus and cyclosporine, have been used as primary immunosuppressant in renal transplantation. Tacrolimus has been shown to be an effective alternative to cyclosporine for the prevention of acute rejection but the two drugs are different in side-effect profile. This retrospective study compares the efficacy and safety of tacrolimus-based versus cyclosporine-based immunosuppression in patients receiving kidney transplantation. METHODS: There were 177 consecutive recipients of kidney graft; 90 received cyclosporine-based immunosuppression therapy, and 87 received tacrolimus-based immunosuppression. Graft and patient survival rate, incidence of acute rejection and side effects were compared. RESULTS: The 3-year graft survival rate of cyclosporine and tacrolimus was similar (93.0% vs. 91.4%). The incidence of acute rejection was significantly less in the tacrolimus group compared with the cyclosporine group (10.3% vs. 31.1%, P<0.05). Incidence of impaired renal function, gastrointestinal disorder, tremor, hypertension and hyperkalemia were comparable in both treatment groups. Higher incidence of posttransplant diabetes, allopecia, abdominal pain and headache was reported in the tacrolimus group, whereas that of hypercholesterolmeia, hirsuitism, and gum hyperplasia was more frequent with cyclosporine group. CONCLUSION: Tacrolimus is as effective as cyclosporine in patient and graft survival in kidney transplantation. Due to different side-effect profiles, it is needed to develop individualized immunosuppressive strategies in renal transplant recipients.
