The pathogen distribution and its influence on inflammatory factors in old patients with heart failure complicated with pulmonary infection
- VernacularTitle:老年心力衰竭合并肺部感染患者病原菌分布及其对 血炎性因子水平影响研究
- Author:
Hu ZHAI
1
Author Information
1. Department of Cardiology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China
- Publication Type:Journal Article
- Keywords:
heart failure;
pneumonia, bacterialpulmonary infection;
pathogen distribution;
cardiac function;
pulmonary function;
inflammatory factors
- From:
Tianjin Medical Journal
2018;46(9):952-955
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathogen distribution, changes of cardiorespiratory function and changes of
serum inflammatory factors in old patients with cardiac failure complicated with pulmonary infection. Methods A total of
153 cardiac failure patients hospitalized in our hospital from March 2014 to September 2017 were retrospectively analyzed.
The patients were divided into pulmonary infected group (n=76) and non-infected group (n=77). Another 82 healthy subjects
were served as control group. The respiratory secretions were collected to detect pathogen distribution in infected group. The
changes of cardiac and pulmonary functions and peripheral blood inflammatory factors were compared between the three
groups. Results A total of 110 pathogens were isolated from infected group, which contained 81 (73.63%) gram negative
strains, 27 (24.55%) gram positive strains and 2 (1.82%) fungus. Compared with the control group and non-infected group,
the lung function index and pulmonary function decreased significantly in the infected group, containing forced expiratory
volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC, carbon monoxide diffusing capacity (DLCO), maximum
mid expiratory flow (MMEF), left ventricular end-diastolic dimension (LVEDD) and left ventricular end-systolic dimension
(LVESD). Meanwhile, the serum levels of tumor necrosis factor (TNF) –α, interleukin (IL)-6 and procalcitonin (PCT) were
significantly higher in the infected group than those in the non-infected group and the control group (P＜0.05).
Conclusion Gram negative strains dominate in pulmonary infection of old patients with cardiac failure, and the cardiopulmonary
function is significantly decreased due to the infection, whereas the serum levels of inflammatory factors are
dramatically increased, which has an auxiliary value in the evaluation of pulmonary infection.
