Meta-analysis of total thyroidectomy for multinodular goiter.
10.11817/j.issn.1672-7347.2014.06.013
- Author:
Hongtai CAO
1
,
2
;
Jixiang HAN
;
Donghong ZHANG
;
Zeyuan YU
;
Mancai WANG
;
Zuoyi JIAO
Author Information
1. Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou 730030
2. Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730030, China.
- Publication Type:Journal Article
- MeSH:
Goiter, Nodular;
surgery;
Humans;
Hypoparathyroidism;
Randomized Controlled Trials as Topic;
Recurrence;
Thyroidectomy;
methods;
Vocal Cord Paralysis
- From:
Journal of Central South University(Medical Sciences)
2014;39(6):625-631
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate the efficiency and safety of total thyroidetomy (including near-total tyhroidectomy) versus subtotal thyroidectomy for multinodular goiter.
METHODS:The literatures were searched from Cochrane Library, PubMed, Embase, Chinese Biological Medical Datebase, Chinese National Knowledge Infrastructure, and Chinese Science and Technology Journal Full-text Database as of November 2013. We included all randomizad controlled trials on total (including near-total) versus subtotal thyroidectomy in the treatment of multinodular goiter. The collecting of data and quality assessment were respectively completed by 2 researchers. RevMan5.1 software was used for Meta-analysis.
RESULTS:We collected 7 literatures conforming to the standard, incuding 2 192 patients. The Metaanalysis outcomes showed that total thyroidectomy was associated with lower nodule recurrence rate (OR=0.13, 95% CI: 0.07-0.22, P<0.001) and higher in transient hypoparathyroidism rate (OR=2.33, 95% CI: 1.72-3.17, P<0.001). However, no statistical difference was seen comparing total and subtotal thyroidectomy in permanent recurrent laryngeal nerve paralysis rate (OR= 0.81, 95% CI: 0.24-2.74, P=0.74) and permanent hypoparathyroidism rate (OR=2.94, 95% CI: 0.48- 18.11, P=0.24).
CONCLUSION:Nodule recurrence rate of total thyroidectomy for multinodular goiter is lower than subtotal thyroidectomy and does not increase permanent complications.
