Expression of the HIF-2α in epithelial ovarian cancer and clinical significance.
10.11817/j.issn.1672-7347.2014.09.004
- Author:
Qin WANG
1
;
Kuan PENG
;
Ling HE
Author Information
1. Department of Obstetrics and Gynecology, Second Xiangya Hospital, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Basic Helix-Loop-Helix Transcription Factors;
metabolism;
Carcinoma, Ovarian Epithelial;
Disease Progression;
Female;
Humans;
Immunohistochemistry;
Neoplasms, Glandular and Epithelial;
diagnosis;
metabolism;
Ovarian Neoplasms;
diagnosis;
metabolism;
Prognosis
- From:
Journal of Central South University(Medical Sciences)
2014;39(9):889-893
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of hypoxia inducible factor 2α (HIF-2α) in every clinical stage and the pathological grade of epithelial ovarian cancer, and to discuss the role of HIF-2α in carcinogenesis, progression and outcomes of epithelial ovarian tumors.
METHODS:Protein expression of HIF-2α in epithelial ovarian tissue from 77 randomly selected specimens was detected by SP immunohistochemistry staining. The relation between the expression of HIF-2α and prognosis of 40 patients with epithelial ovarian cancer was analyzed by Cox regression model.
RESULTS:There was positive relation between the positivity rates of HIF-2α and malignant grade, FIGO stage, histological grade and invasive metastasis. The live time of the patients with HIF-2α positive expression was shorter than those with negative expression.
CONCLUSION:HIF-2α may play an important role in the genesis, development, invasion and metastasis of ovarian cancer and it may possess the vital clinical significance for prognosis evaluation.
