Recent advances in the study of synaptic endocytosis key protein: Dynamin.
10.11817/j.issn.1672-7347.2014.10.018
- Author:
Ting CAI
1
;
Wei YUAN
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Southwest Hospital of the Third Military Medical University, Chongqing 400038, China.
- Publication Type:Journal Article
- MeSH:
Clathrin;
physiology;
Coated Pits, Cell-Membrane;
physiology;
Dynamins;
physiology;
Endocytosis;
Humans;
Synapses;
physiology;
Synaptic Transmission;
Synaptic Vesicles;
physiology
- From:
Journal of Central South University(Medical Sciences)
2014;39(10):1088-1092
- CountryChina
- Language:Chinese
-
Abstract:
As the basic physiological function of synapses, vesicle cycling involves in many aspects of process. Among them, vesicle recycling is the basis of synaptic vesicle cycling. Studies show that clathrin mediated endocytosis is a major pathway of vesicle recycling, in which Dynamin plays an important role. Dynamin is a GTPases with molecular weight of 100 kD, which acts as "scissors" in the endocytosis, separating the clathrin coated pits from membrane. It has been found that Dynamin is associated with epilepsy, Alzheimer's disease, centronuclear myopathy, and several other neurological diseases. In this paper, we discussed the structure, function and regulation of Dynamin, and reviewed recent advance in the studies on Dynamin related diseases.
