Changes of plasminogen activator inhibitor-1 and D-dimer during continuous blood purification and related factors.
10.11817/j.issn.1672-7347.2014.01.012
- Author:
Jianwen WANG
1
;
Youming PENG
;
Hao ZHANG
;
Bin YI
;
Ke ZHANG
;
Jun LIU
;
Jishi LIU
Author Information
1. Department of Nephrology, Third XianYa Hospital, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Anticoagulants;
therapeutic use;
Fibrin Fibrinogen Degradation Products;
analysis;
Heparin;
therapeutic use;
Humans;
Interleukin-1beta;
blood;
Plasminogen Activator Inhibitor 1;
blood;
Renal Dialysis;
Tumor Necrosis Factor-alpha;
blood
- From:
Journal of Central South University(Medical Sciences)
2014;39(1):67-72
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the changes of plasminogen activator inhibitor-1 and D-dimer during continuous blood purification (CBP) and related factors.
METHODS:Sixteen patients who were diagnosed with multiple organ dysfunction syndrome (MODS) were randomly divided into 2 groups: 8 patients received standard continuous blood purification with heparin anticoagulation, and the other 8 received CBP without anticoagulation. Ten normal blood samples were collected from healthy volunteers as controls. All patients underwent CBP for 8 h. Blood was taken from those patients at 0, 15, 60, 120 and 480 min during the CBP. Plasma plasminogen activator inhibitor-1, D-dimer and serum TNF-α and IL-1β were measured by ELISA.
RESULTS:Plasma levels of PAI-1 and D-dimer were increased significantly compared with those in the control group (P<0.05). Plasma level of PAI-1 was reduced (P<0.05) and D-dimer was increased (P<0.05) after the CBP. The level of plasma PAI-1 in the heparin group was significant reduced compared with the group of CBP without anticoagulation (P<0.05). There was negative correlation between the level of PAI-1 and the dosage of heparin used during a CBP session in the heparin group (r=-0.746, P<0.001).
CONCLUSION:The level of PAI-1 and D-dimer is higher in patients with MODS than that in the normal controls. After the CBP treatment, there is significant decrease in PAI-1 and increase in D-dimer in both groups. Heparin used during CBP can reduce PAI-1 which intensifies its function of anticoagulation.
