Immune pathogenesis of IgA nephropathy and its drugable targets.
10.11817/j.issn.1672-7347.2014.01.016
- Author:
Liyu HE
1
;
Hong LIU
;
Youming PENG
Author Information
1. Department of Nephrology, Sencond Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Antigen-Antibody Complex;
B-Lymphocytes;
Glomerular Mesangium;
Glomerulonephritis, IGA;
pathology;
Humans;
Immunoglobulin A;
chemistry;
T-Lymphocytes
- From:
Journal of Central South University(Medical Sciences)
2014;39(1):96-101
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy (IgAN) is recognized as the most common immune complex related to the cause of glomerulonephritis worldwide. The disease is characterized by the predominant deposition of underglycosylated IgA1 in the mesangial area of glomeruli. Dysregulation of the immune system plays an important role in the pathogenesis of IgAN. Abnormalities restricted to T lymphocytes and/or B lymphocytes activation could be a critical causative factor in the over-production of underglycosylated IgA1.
