Changes of blood pressure and S-100B, neuron specific enolase protein in hypertensive dogs after renal sympathetic denervation.
10.11817/j.issn.1672-7347.2014.03.004
- Author:
Fenglin JIANG
1
;
Xinguo WANG
;
Fuyin ZHU
;
Lixiong ZENG
;
Xiaoyan WANG
;
Hui LI
;
Zhijie SHEN
;
Kan YANG
;
Zhihui ZHANG
Author Information
1. Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Pressure;
Catheter Ablation;
Dogs;
Hypertension;
metabolism;
Kidney;
innervation;
surgery;
Phosphopyruvate Hydratase;
metabolism;
S100 Calcium Binding Protein beta Subunit;
metabolism;
Sympathectomy
- From:
Journal of Central South University(Medical Sciences)
2014;39(3):245-251
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the changes of blood pressure and S-100B, neuron specific enolase (NSE) protein in hypertensive dogs with high fat diet after catheter-based renal sympathetic denervation.
METHODS:Twelve Beagles were divided into an interventional group (n=6) and a sham-operation group (n=6). After baseline measurements, the Beagles were fed with lard oil for 3 months. After 3 months, the interventional group had renal sympathetic denervation by percutaneous catheter based radiofrequency ablation and the control group had renal angiography. The blood pressure, plasma S-100B, and NSE before the operation and 3 days, 1 week, 2 weeks, 1 month, 2 months and 3 months after the operation were measured.
RESULTS:The dogs had significantly higher levels of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MBP) compared to its baselines (P<0.05). The SBP, DBP and MBP in the interventional group were significantly lower than those in the control group 1 month and 3 months after the operation (P<0.05). Three months after the operation, renal angiography in all dogs revealed no sign of renal artery stenosis. Plasma S-100B and NSE expression in the interventional group were higher than those in the control group 3 days, 1 week and 2 weeks after the operation (P<0.05).
CONCLUSION:Renal sympathetic denervation can significantly reduce the SBP, DBP and MBP in hypertensive dogs. The plasma S-100B and NSE may be used as indicators for assessment of renal nerve injury after renal sympathetic denervation.
