Carotid intima-media thickness and estimated glomerular filtration rate in hypertensive patients.
10.3969/j.issn.1672-7347.2014.05.005
- Author:
Pingting YANG
1
;
Hong YUAN
;
Chunyan WENG
;
Yaqin WANG
;
Xia CAO
;
Zhiheng CHEN
Author Information
1. Health Management Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Atherosclerosis;
Blood Pressure;
Carotid Arteries;
diagnostic imaging;
pathology;
Carotid Artery Diseases;
Carotid Intima-Media Thickness;
Female;
Glomerular Filtration Rate;
Humans;
Hypertension;
physiopathology;
Male;
Middle Aged;
Renal Insufficiency, Chronic;
Risk Factors;
Smoking
- From:
Journal of Central South University(Medical Sciences)
2014;39(5):465-470
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the association between carotid atherosclerosis and renal function in hypertensive patients.
METHODS:A total of 2 809 hypertensive patients aged (56.59±10.79) years were enrolled. Carotid intima-media thickness (cIMT) was derived via B-mode ultrasonography and chronic kidney disease (CKD) was evaluated by the estimated glomerular filtration rate (eGFR) with Cockcroft- Gault method. The patients were divided into 3 groups: a normal group, a thick group, and a plaque group according to the results of carotid ultrasonography.
RESULTS:The eGFR of the normal group was (111.09±25.61) mL/(min.1.73m(2)), that of the thick group and the plaque group was (94.45±27.14) mL/(min.1.73m(2)) and (85.98±26.92) mL/ (min.1.73m(2)). Binary logistic analysis showed that age (OR=3.590), smoking status (OR=1.543), systolic blood pressure (OR=1.018), diastolic blood pressure (OR=0.977), fasting plasma glucose (OR=1.132), triglyceride (OR=0.873) and eGFR (OR=0.986) were significantly correlated with cIMT. Subgroup analyses on different genders showed that eGFR was a significant independent risk factor in men (OR=0.991) but not in women.
CONCLUSION:The thicker the cIMT, the lower the eGFR in hypertensive patients. With the development of cIMT, eGFR gradually decreases and contributes to the occurrence and development of early-stage atherosclerosis in hypertensive patients.
