hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang.
10.11817/j.issn.1672-7347.2014.06.002
- Author:
Haiyan WANG
1
;
Zhenqiang SUN
;
Ligong YE
;
Pei XU
;
Yunxia ZHAO
;
Lina TANG
;
Xiaoyi DUN
Author Information
1. Department of Blood, Enterology and Endocrinology, Chinese PLA 474 Hospital, Urumqi 830011,China.
- Publication Type:Journal Article
- MeSH:
Colorectal Neoplasms;
genetics;
metabolism;
Humans;
Immunohistochemistry;
MutS Homolog 2 Protein;
genetics;
metabolism;
Prognosis
- From:
Journal of Central South University(Medical Sciences)
2014;39(6):552-557
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the significance of hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang Uygur Autonomous Region.
METHODS:Clinicopathological parameters and postoperative samples of 327 patients with sporadic colorectal cancer were collected in Xinjiang Uygur Autonomous Region. Immunohistochemistry PV-9000 two-step method was performed to measure hMSH2 expression in the postoperative pathologic specimens. Prognostic value of hMSH2 expression was evaluated.
RESULTS:Thirty-five (10.7%) patients showed aberrant nuclear staining of hMSH2 expression. The patients with aberrant expression of hMSH2 showed better prognosis than the normal expression group, with significant difference (P<0.05).
CONCLUSION:In Xinjiang, aberrant hMSH2 expression can be regarded as an independent prognostic factor in patients with sporadic colorectal cancer.
