Long noncoding RNAs in gene expression control.
10.11817/j.issn.1672-7347.2014.11.017
- Author:
Yinghui LI
1
;
Hui FU
Author Information
1. Department of Anatomy and Embryology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Nucleus;
genetics;
Gene Expression Regulation;
Humans;
MicroRNAs;
genetics;
RNA, Long Noncoding;
RNA, Messenger;
genetics;
Transcription Factors;
genetics
- From:
Journal of Central South University(Medical Sciences)
2014;39(11):1204-1210
- CountryChina
- Language:Chinese
-
Abstract:
Studies have shown that most of the sequence in the mammalian genome is transcribed into long noncoding RNAs (lncRNAs). Their crucial roles in gene regulation are becoming a hotspot in current biomedical research. LncRNAs can control gene activities through multiple mechanisms such as: 1) direct or indirect regulation of gene expression via cis-/trans-action or function as protein baits in the nucleus; 2) affecting the stability and the translational process of mRNA; 3) functioning as competitors to regulation of microRNA; 4) binding to transcription factors. Recent studies have highlighted the significance of lncRNAs in development and diseases, and their potentials in future clinical application.
