Impact of sitagliptin on aspirin resistance in patients with Type 2 diabetes mellitus.
10.11817/j.issn.1672-7347.2015.11.004
- Author:
Yanhua LI
1
;
Lezhi LI
1
;
Meijun OU
1
;
Xuefeng XU
2
;
Ming LI
3
;
Chenyang CHEN
4
Author Information
1. Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011, China.
2. Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
3. Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
4. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Aspirin;
pharmacology;
Blood Glucose;
analysis;
C-Reactive Protein;
analysis;
Diabetes Mellitus, Type 2;
drug therapy;
Drug Resistance;
Glycated Hemoglobin A;
analysis;
Humans;
Hypoglycemic Agents;
pharmacology;
Metformin;
pharmacology;
Oxidative Stress;
Sitagliptin Phosphate;
pharmacology
- From:
Journal of Central South University(Medical Sciences)
2015;40(11):1186-1191
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the impact of sitagliptin on aspirin resistance (AR) in patients with Type 2 diabetes mellitus (T2DM).
METHODS:A total of 68 cases of AR were chosen from 136 cases of T2DM patients. The clinical data, including blood samples, fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), and high sensitive C reactive protein (hs-CRP) were collected. Aenosine diphosphate (ADP) and arachidonic acid (AA) -induced platelet aggregation rate (PAG) were detected in 1, 3, 6 and 12 months after the treatment to evaluate the impact of sitagliptin on AR.
RESULTS:After 6 months of hypoglycemic treatment, FPG and HbAlc in two groups were at the normal level. The hypoglycemic effect was not obviously different (P>0.05), but the hsCRP and ADP or AA-induced PAG were decreased in the sitagliptin group with statistical significance when compared with the metformin group (P<0.05).
CONCLUSION:Sitagliptin can significantly improve the oxidative stress inflammatory state in T2DM patients and AR, which is independent on blood glucose control.
