Pulmonary Inflammatory Cells in Preterm Infants with Respiratory Distress Syndrome Followed by Surfactant Treatment.
- Author:
Hyeon Soo LEE
1
;
Myung Seo KANG
Author Information
1. Department of Pediatrics, Pundang Jesaeng General Hospital.
- Publication Type:Original Article
- Keywords:
Inflammatory cells;
Macrophage;
Respiratory distress syndrme;
Bronchoalveolar lavage fluid
- MeSH:
Bronchoalveolar Lavage;
Bronchoalveolar Lavage Fluid;
Cell Count;
Humans;
Infant, Newborn;
Infant, Premature*;
Macrophages;
Parturition;
Respiration, Artificial
- From:Journal of the Korean Pediatric Society
1999;42(5):644-649
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The effect of surfactant treatment on inflammatory cell populations has not been determined. I evaluated the effect of surfactant treatment on a number and distribution of inflammatory cells in bronchoalveolar lavage fluid(BALF) from the preterm infants who were dependent on mechanical ventilation over the 1st week of life. METHODS: This study included 8 preterm infants with respiratory distress syndrome(RDS) who received surfactant(Exosurf, 67.5mg/kg Dipalmitoyl phosphatidylcholine(DPPC) with a volume of 5 ml/kg, single dose)on their first day of life and 7 preterm infants of similar severity who did not. BALFs were collected on days 2, 3, 5, and 7 after birth. Cell counts were performed from the obtained BALFs, then they were applied to cytospin and Wright stain, and the differentials were calculated on 200 cells. RESULTS: Surfactant treatment had no significant effect on the number of BALF white cells on days 2-7. Polymorphonuclear cell numbers were not different in both groups on days 2 7. Macrophage cell numbers were higher overall in surfactant treated babies compared to those in untreated babies on days 2-7(P<0.05). CONCLUSION: Surfactant treatment appeared to accelerate the appearance of macrophages in BALF.
