Role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia.
10.11817/j.issn.1672-7347.2015.12.005
- Author:
Liqiao GE
1
;
Ting MING
2
;
Jin HOU
3
;
Jing YAN
3
;
Qiang WANG
4
;
Feng QIAO
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, The First Hospital Affiliated to Xi'an Medical University, Xi'an 710077, China.
2. Department of Anesthesia, The First Hospital Affiliated to Xi'an Medical University, Xi'an 710077, China.
3. Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
4. Department of Infection Control, The First Hospital Affiliated to Xi'an Medical University, Xi'an 710077, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Blotting, Western;
Hypoxia;
physiopathology;
Lung;
metabolism;
pathology;
Lung Injury;
metabolism;
physiopathology;
Rats;
Transcription Factor RelA;
metabolism;
p38 Mitogen-Activated Protein Kinases;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2015;40(12):1313-1319
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia.
METHODS:Experiment were divided into a control group and a hypoxia group (n=20). After 5 weeks of hypoxia treatment, the expression of NF-κB p65 and p38 MAPK in lung tissues of rats were detected by optical microscope and immunohistochemical techniques and Western blot.
RESULTS:Pathological examination showed pulmonary interval thickness was (0.45 ± 0.12) μm and (2.15 ± 0.49) μm in the control and hypoxia group, respectively (P<0. 05). Compared with the control group, the levels of both NF-κB p65 and p38 MAPK were increased in the hypoxia group (P<0. 01), which were confirmed by Western blot.
CONCLUSION:NF-κB p65 and p38 MAPK may play important roles in lung injury reconstruction in of the rats treated by chronic intermittent hypoxia.
