Clinical features of patients with primary biliary cirrhosis.
10.11817/j.issn.1672-7347.2015.12.008
- Author:
Lifen HE
1
;
Yijie LAI
2
;
Liying LAI
1
;
Kaizhong LUO
1
;
Wenlong WANG
1
;
Yi TIAN
1
;
Guozhong GONG
1
;
Min ZHANG
1
Author Information
1. Research Center of Liver Disease, Second Xiangya Hospital, Central South University, Changsha 410011, China.
2. Grade 2012, School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200240, China.
- Publication Type:Journal Article
- MeSH:
Alkaline Phosphatase;
metabolism;
Autoantibodies;
blood;
Female;
Humans;
Liver Cirrhosis, Biliary;
diagnosis;
pathology;
Male;
Mitochondria;
Retrospective Studies;
gamma-Glutamyltransferase;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2015;40(12):1333-1339
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine features of the clinical manifestation in patients with primary biliary cirrhosis (PBC), and to provide a scientific basis for diagnosis of PBC.
METHODS:A total of 102 patients with PBC treated in the Second Xiangya Hospital, Central South University, from January 2013 to January 2015 were retrospectively analyzed. The patients' general condition, clinical manifestations, serum biochemical and immunological parameters were detected.
RESULTS:Of the 102 PBC patients, 91 (89.21%) patients were female. The main symptoms in these patients were fatigue, poor appetite, dry mouth, nausea, vomiting, pruritus, stomachache, and abdominal distension. The major signs were jaundice, splenomegaly, hepatomegaly, edema, and ascites. The main features of serum biochemical parameters in these patients included the increase of alkaline phosphatase and gamma glutamyltranspeptidase (GGT), especially the GGT. The anti-mitochondrial antibodies-M2 (AMA-M2) in 81 and 21 patients was positive and negative, respectively. The differences between the AMA-MA positive and negative groups were not statistically significant (P>0.05). According to clinical manifestation, 102 patients were classified into 2 groups: A non-cirrhosis group (n=56) and a cirrhosis group (n=46). The positive rates in these 2 groups, such as ANA, AMA-M2, anti-gp210, anti-Sp100, anti-Ro52, anti-PML, were 54.35%, 89.13%, 41.30%, 13.04%, 43.38% and 10.87% vs 57.14%, 71.43%, 42.86%, 12.5%, 51.79% and 3.71%, respectively, with no significant difference between them (P>0.05). However, there was significant difference in the positive rate of anti-3E-EPO between the above 2 groups (86.78% vs 58.93%, P<0.05). The positive rates of AMA-M2 and anti-3E-EPO in 30 patients diagnosed by hepatic histopathological examination were higher than those of other antibodies.
CONCLUSION:PBC mainly affects middle-aged women, and its clinical manifestation is various. The autoantibody tests play an important role in diagnosis of PBC. Checking for AMA-A2 and anti-3E-BPO can improve the positive rate of PBC. Liver histopathological examination may provide useful information on disease severity, which can determine the histological stage when the patient's serum autoantibodies are negative.
