Screening of the anti-tumor active fraction from Ipomoea batatas Lam. (cv.simon) leaves.
10.11817/j.issn.1672-7347.2015.05.007
- Author:
Shuhe LÜ
1
,
2
;
Cong LIN
;
Pingsheng XU
Author Information
1. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008
2. School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
Cell Line, Tumor;
Humans;
Ipomoea batatas;
chemistry;
Plant Extracts;
chemistry;
Plant Leaves;
chemistry
- From:
Journal of Central South University(Medical Sciences)
2015;40(5):499-503
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Three fractions (SM, SM-A, SM-B) were prepared from different polarity parts of Ipomoea batatas Lam. (cv.simon) leaves and the anti-tumor potency as well as the dose-response relations were evaluated.
METHODS:The anti-tumor activities of fraction SM, SM-A or SM-B were screened by MTS in human hepatic cancer Hep3B cells, lung cancer A549 cells or gastric carcinoma MGC803 cells, respectively.
RESULTS:The three fractions all showed anti-tumor activities in three cancer cells with different sensitivity. Among them, SM-B was the most potent fraction with IC50 values at 15.17 mg/L, 72.64 mg/L or 165.47 mg/L in MGC803 cells, A549 cells or Hep3B cells, respectively (P<0.05).
CONCLUSION:Th e extraction of Brazil sweet potato leaves displayed anti-tumor activity and SM-B was the most potent fraction.
