COMT genetic variation and clinical response to antipsychotic drug treatment: A Meta-analysis.
10.11817/j.issn.1672-7347.2015.06.009
- Author:
Hui CHEN
1
;
Jiao TU
1
;
Ping NI
1
;
Wei ZHANG
2
;
Linyong XU
3
,
4
Author Information
1. Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078,China.
2. Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008,China.
3. Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078
4. Clinical Drug Research and Statistical Analysis Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Antipsychotic Agents;
therapeutic use;
Catechol O-Methyltransferase;
genetics;
Humans;
Polymorphism, Genetic
- From:
Journal of Central South University(Medical Sciences)
2015;40(6):623-631
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To examine the relationship between COMT polymorphisms and the response to antipsychotic drugs, and then provide a basis for personalized medicine of antipsychotic drugs.
METHODS:We performed a systematic search from PubMed, Embase, Cochrane Library, CBM, CNKI, VIP and Wanfang database for eligible studies. Stata 12.0 was used for Meta-analysis after evaluating the quality of studies and collecting the data.
RESULTS:Nine studies included 868 participants met inclusion criteria. Significant association was found between the COMT Val108/158Met gene polymorphism and antipsychotic drug efficacy. Evaluating the therapeutic efficacy through general symptoms: Met vs Val, RR=1.18, 95% CI: 1.04-1.35, P=0.013; Met/Met vs Val/Val, RR=1.40, 95% CI: 1.08-1.82, P=0.010. Evaluating the therapeutic efficacy through negative symptoms: Met vs Val, RR=1.24, 95% CI: 1.05-1.46, P=0.013; Met/Met vs Val/Val, RR=1.60, 95% CI: 1.04-2.46, P=0.031.
CONCLUSION:COMT Val108/158Met gene polymorphism is significantly associated with antipsychotic drug efficacy, and Met gene is a dominant gene which displays a better response to antipsychotic drugs.
