1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and
cognitive dysfunction.
10.11817/j.issn.1672-7347.2015.06.011
- Author:
Xiaoshuang XIANG
1
,
2
;
Xuan HOU
3
;
Zhanfang SUN
3
;
Gaofeng ZHOU
4
;
Beisha TANG
5
;
Hong JIANG
5
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008
2. Department of Neurology, Xiangxi Autonomous Prefecture People's Hospital, Jishou Hunan 416000, China.
3. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
4. Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
5. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008.
- Publication Type:Journal Article
- MeSH:
Aspartic Acid;
analogs & derivatives;
metabolism;
Choline;
metabolism;
Cognition Disorders;
physiopathology;
Creatine;
metabolism;
Frontal Lobe;
metabolism;
Humans;
Inositol;
metabolism;
Multiple System Atrophy;
physiopathology;
Proton Magnetic Resonance Spectroscopy
- From:
Journal of Central South University(Medical Sciences)
2015;40(6):639-645
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect metabolic changes of bilateral frontal lobe in patients with multiple system atrophy (MSA) and cognitive dysfunction by 1H-proton magnetic resonance spectroscopy (1H-MRS).
METHODS:N-acetylaspartate (NAA)/creatine(Cr), choline (Cho)/Cr, myoinositol (mI)/Cr in three sides of frontal lobe were detected by 1H-MRS in 48 healthy controls, 23 patients with MSA and cognitive dysfunction and 19 patients with MSA but without cognitive dysfunction.
RESULTS:NAA/Cr of bilateral frontal lobes in patients with MSA and cognitive dysfunction was significantly decreased compared with MSA patients without cognitive dysfunction and healthy controls (P<0.05). mI/Cr of right frontal lobes was significantly increased in patients with MSA and cognitive dysfunction compared with healthy controls (P<0.05). There was a negative correlation between NAA/Cr of bilateral frontal lobes and duration while a positive correlation between NAA/Cr of bilateral frontal lobes and MoCA score in patients with MSA and cognitive dysfunction.
CONCLUSION:There is a decrease in NAA/Cr and an increase in mI/Cr in frontal lobes in patients with MSA and cognitive dysfunction, which may be associated with cognitive dysfunction in MSA patients.
