Changes in CD40 expression in the pallium and hippocampus in epileptic rats.
10.11817/j.issn.1672-7347.2015.07.005
- Author:
Hong SUN
1
;
Huifeng ZHANG
2
;
Haiqin WU
3
;
Jing REN
4
;
Guilian ZHANG
3
;
Ru ZHANG
3
;
Shuqin ZHAN
3
Author Information
1. Department of Neurology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China sunhongxjt@163.com.
2. Department of Encephalopathy,
Xi'an Electric Central Hospital, Xi'an 710032, China.
3. Department of Neurology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
4. Department of Plastic and Aesthetic Surgery, Second Affiliated Hospital,
Xi'an Jiaotong University, Xi'an 710004, China.
- Publication Type:Journal Article
- MeSH:
Animals;
CD40 Antigens;
metabolism;
Epilepsy;
Hippocampus;
metabolism;
Immunohistochemistry;
Lithium;
Microglia;
metabolism;
Pilocarpine;
Rats;
Rats, Sprague-Dawley;
Status Epilepticus
- From:
Journal of Central South University(Medical Sciences)
2015;40(7):729-734
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of inflammatory molecule CD40 in the pallium and hippocampus of rats after status epilepticus (SE).
METHODS:The expression of CD40 in the pallium, the different areas of hippocampus and the different cells from the lithium-pilocarpine epileptic rats at different time points were examined by immunohistochemistry and double-immunofluorescent labeling.
RESULTS:After SE, CD40 expression was obviously inhibited, especially in hippocampus. CD40 was mainly expressed in the activated microglia. CD40 positive cells reached a peak at the 3rd day and returned to a slightly higher level at the 7th day after SE compared with the level before SE.
CONCLUSION:Elevation of CD40 expression in the activated microglia can promote inflammatory injury of rat's hippocampus, suggesting that CD40 induced-signal pathway is involved in inflammatory injury in the hippocampus after SE.
