WEE1, histone and tumor.
10.11817/j.issn.1672-7347.2015.07.017
- Author:
Bin LIU
1
Author Information
1. Department of Urology, Third Xiangya Hospital, Central South University, Changsha 410013, China 25634849@qq.com.
- Publication Type:Journal Article
- MeSH:
CDC2 Protein Kinase;
metabolism;
Cell Cycle;
Cell Cycle Proteins;
metabolism;
DNA Damage;
Histones;
metabolism;
Humans;
Neoplasms;
metabolism;
Nuclear Proteins;
metabolism;
Phosphorylation;
Protein-Tyrosine Kinases;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2015;40(7):806-810
- CountryChina
- Language:Chinese
-
Abstract:
WEE1 is an important factor for histone transcription, chromosome condensation and regulation of cell cycle progression. WEE1 kinase can phosphorylate Cdc2 and down-regulate Cdc2 kinase activity. It can regulate G2 to M phase transition and cell mitosis. It plays a key role in chromosome condensation delay and histone synthesis, suggesting the important functions of WEE1 in the occurrence and development in cancer. At present, a multiple WEE1 inhibitors have been discovered. A great progress has been made in combination of WEE1 inhibitors with DNA damage treatment (chemotherapy or radiotherapy), which makes WEE1 an important target in cancer treatment.
