Toll-like receptors and non-resolving inflammation-related cancer.
10.11817/j.issn.1672-7347.2015.02.015
- Author:
Chunlin OU
1
,
2
,
3
,
4
;
Han ZHANG
;
Zhenqiang SUN
;
Guiyuan LI
;
Xiaoling LI
;
Xiayu LI
Author Information
1. Key Laboratory of Carcinogenesis of Ministry of Health
2. Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education
3. Disease Genome Research Center, Central South University
4. Cancer Research Institute, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Inflammation;
Neoplasm Invasiveness;
Neoplasm Metastasis;
Neoplasms;
Toll-Like Receptors;
Tumor Microenvironment
- From:
Journal of Central South University(Medical Sciences)
2015;40(2):202-207
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors (TLRs) is a type of pattern recognition receptors (PRRs), which are singular, non-catalytic and highly homologous. TLRs not only play significant roles in natural immunity, but also act as a bridge between innate immunity and adaptive immunity. Recent studies have revealed that TLRs play critical roles in the development of non-resolving inflammation-related cancer,including the formation of tumor microenvironment, invasion and metastasis, immune escape, etc. Further investigation into the mechanisms responsible for the function of TLRs will be of great value in tumor prevention, early diagnosis and therapy.
