Effect and mechanism of fluorofenidone on organ fibrosis.
10.11817/j.issn.1672-7347.2015.02.016
- Author:
Hong MA
1
;
Zhangzhe PENG
;
Gaoyun HU
;
Lijian TAO
Author Information
1. Department of Nephrology, Xiangya Hospital, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Extracellular Matrix;
Fibrosis;
Humans;
Kidney;
pathology;
Liver Cirrhosis;
Pulmonary Fibrosis;
Pyridones;
pharmacology;
Signal Transduction
- From:
Journal of Central South University(Medical Sciences)
2015;40(2):208-213
- CountryChina
- Language:Chinese
-
Abstract:
Fibrosis can occur in different organs with high incidence rate and great danger. It still lacks effective drugs for prevention of fibrosis. Fluorofenidone is a newly developed drug with anti-fibrotic activity, which provides a new hope for treating the progressive fibrotic diseases. Recent studies have shown that fluorofenidone is a multifunctional small molecule with anti-inflammatory, antioxidative and anti-apoptotic eff ects. It can inhibit the activation and proliferation of myofibroblasts, promote the degradation of extracellular matrix and regulate the cellular signal transmission. Fluorofenidone can be applied to attenuate the progression of renal, hepatic and pulmonary fibrosis.
