Expression of 5-lipoxygenase in human tissues and its association with disease.
10.11817/j.issn.1672-7347.2015.04.017
- Author:
Shishu TANG
1
;
Jian'an HU
Author Information
1. Department of Occupational and Environmental Health, School of Public Health, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Arachidonate 5-Lipoxygenase;
physiology;
Atherosclerosis;
enzymology;
Humans;
Inflammation;
enzymology;
Neoplasms;
enzymology
- From:
Journal of Central South University(Medical Sciences)
2015;40(4):438-445
- CountryChina
- Language:Chinese
-
Abstract:
5-Lipoxygenase, one of lipoxygenase isozymes, is a well-studied oxidative metabolism enzyme. It widely exists in various human tissues and cells, participates in the oxidative metabolism of endogenous and exogenous chemicals, and produces a variety of metabolites, all of which contribute to the occurrence of human diseases, such as inflammation, asthma, atherosclerosis, and tumor and so on. The expression of 5-lipoxygenase is at low level in normal human tissues while at high level in abnormal tissues. 5-Lipoxygenase is closely related to many kinds of diseases in human ovary, brain, cardiovascular system, lung, liver, pancreas and other tissues. The abnormal expression of 5-lipoxygenase tends to promote the development of the disease.
