Protective effect of right coronary artery ischemic preconditioning on myocardial ischemia reperfusion injury
in rabbit heart.
- Author:
Jun LI
1
;
Guoqiang LIN
2
;
Rimao HUANG
2
;
Huihui LU
1
;
Zhong YANG
1
;
Wanjun LUO
2
Author Information
1. Department of Cardiothoracic Surgery, First Affiliated Hospital of Hunan Traditional Chinese Medical College, Zhuzhou Hunan 412000, China.
2. Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Coronary Vessels;
Creatine Kinase, MB Form;
blood;
Heart;
Ischemia;
Ischemic Postconditioning;
Ischemic Preconditioning;
Ischemic Preconditioning, Myocardial;
Myocardial Infarction;
etiology;
pathology;
physiopathology;
prevention & control;
Myocardial Ischemia;
complications;
therapy;
Myocardial Reperfusion Injury;
prevention & control;
Myocardium;
Rabbits;
Troponin T;
blood
- From:
Journal of Central South University(Medical Sciences)
2016;41(10):1047-1051
- CountryChina
- Language:Chinese
-
Abstract:
To explore the protective effects of right coronary artery ischemic preconditioning and post-conditioning on myocardial ischemia reperfusion injury in rabbit heart.
Methods: A total of 30 rabbits were randomly divided into 4 groups: a control group (n=7), an ischemia reperfusion group (IR group, n=8), an ischemic preconditioning group (IPC group, n=8) and an ischemic post-conditioning group (IPO group, n=7). Venous blood samples were taken at pre-operation, 1 and 6 h post-operation, and the concentration of serum creatine kinase isoenzyme (CK-MB) and cardiac troponin-T (cTn-T) were measured. The infarct area of cardiac muscle was calculated.
Results: Compared with the IR group, the levels of CK-MB and cTn-T at 1 and 6 h post-operation in the IPC group and the IPO group were reduced (all P<0.05). Compared with the IR group, the infarct size in the IPC group and the IPO group was significantly decreased, with significant difference (both P<0.05) .
Conclusion: Right coronary artery ischemic preconditioning and post-conditioning exert significant protective effects on the myocardial ischemia reperfusion injury in New Zealand rabbits.
