Role of M-type phospholipase A2 receptor and its antibody in hepatitis B virus-associated membranous nephropathy.
- Author:
Xiangqing XU
1
,
2
;
Xuejing ZHU
1
,
2
;
Shuguang YUAN
1
,
2
;
Wenling JIANG
1
,
2
;
Yuncheng XIA
1
,
2
;
Hong LIU
1
,
2
;
Jun LI
1
,
2
;
Lin SUN
1
,
2
;
Youming PENG
1
,
2
;
Fuyou LIU
1
,
2
Author Information
1. Department of Nephrology, Second Xiangya Hospital
2. . Institute of Nephrology, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Antibodies;
Autoantibodies;
genetics;
physiology;
Biopsy;
Glomerulonephritis, Membranous;
complications;
etiology;
genetics;
Hepatitis B;
complications;
Hepatitis B Surface Antigens;
adverse effects;
Hepatitis B virus;
Humans;
Kidney;
blood supply;
chemistry;
physiopathology;
Kidney Diseases;
etiology;
genetics;
physiopathology;
Male;
Prognosis;
Proteinuria;
epidemiology;
genetics;
Receptors, Phospholipase A2;
blood;
physiology;
Serum Albumin;
genetics
- From:
Journal of Central South University(Medical Sciences)
2016;41(10):1064-1068
- CountryChina
- Language:Chinese
-
Abstract:
To examine levels of M-type phospholipase A2 receptor (PLA2R) and its antibody in the patients with hepatitis B virus-associated membranous nephropathy (HBV-MN), and to explore the correlation of PLA2R with laboratory parameters and pathological characteristics.
Methods: A total of 49 adult patients with biopsy-proved HBV-MN were enrolled in this study. Levels of anti-PLA2R antibody in serum and PLA2R in renal tissue were detected. Patients were assigned into two groups: a positive PLA2R group and a negative PLA2R group. Differences in laboratory parameters and pathological characteristics were compared between the two groups.
Results: Of 49 patients with HBV-MN, 17 had positive PLA2R expression in renal tissues. In the positive PLA2R group, 10 patients were positive for serum anti-PLA2R antibody. Patients with positive PLA2R expression in renal tissues showed higher levels of 24 hour urinary protein [(4.6±3.9) g/d], serum HbsAg (70.5%) and renal HbsAg expression (71%), while lower level of serum albumin [(24.1±7.5) g/L] than those of the negative group.
Conclusion: PLA2R is expressed in the renal tissues and serum anti-PLA2R antibody can be detected in some HBV-MN patients. Positive PLA2R expression in renal tissue might be related to HbsAg deposition in serum and renal tissues. Patients with positive PLA2R expression in renal tissue have more severe glomerular sclerosis.
