PRKAR1α expression in non-small cell lung cancer and
its clinicopathologic significance.
- Author:
Shaoqiang WANG
1
;
Yuanda CHENG
1
;
Zhiwei HE
1
;
Wolong ZHOU
1
;
Yang GAO
1
;
Chaojun DUAN
2
;
Chunfang ZHANG
1
Author Information
1. Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
2. Institute of Medical Sciences, Xiangya Hospital,
Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
chemistry;
classification;
genetics;
Adenocarcinoma of Lung;
Biomarkers, Tumor;
Carcinoma, Non-Small-Cell Lung;
chemistry;
genetics;
Carcinoma, Squamous Cell;
chemistry;
genetics;
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit;
physiology;
Female;
Gene Expression Profiling;
Humans;
Immunohistochemistry;
Lung Neoplasms;
chemistry;
classification;
genetics;
Lymphatic Metastasis;
genetics;
Male;
Neoplasm Staging;
RNA, Messenger
- From:
Journal of Central South University(Medical Sciences)
2016;41(11):1148-1154
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the expression of cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1α) in non-small cell lung cancer (NSCLC) and its correlation with clinicopathological features.
Methods: PRKAR1α expressions in 79 NSCLC patients and matched adjacent non-carcinoma tissues were analyzed by using qRT-PCR and immunohistochemistry.
Results: The negative rates of PRKAR1α protein in NSCLC, lung squamous cell carcinoma (SCL) and lung adenocarcinoma (ACL) were 58.2%, 77.8%, 32.4%, respectively. Compared to the matched adjacent non-carcinoma tissues, there were significant differences in levels of PRKAR1α mRNA and protein in ACL (P<0.05), but not in SCL and overall NSCLC (P>0.05). The expression of PRKAR1α protein was positively correlated with histological type, TNM stage, and lymph node metastasis (P<0.05). Tumor size and histogenesis differentiation were not related to the decreased PRKAR1α (P>0.05).
Conclusion: Low expression of PRKAR1α in ACL might be involved in the pathogenesis, which might serve as a novel diagnostic candidate.
