Effect of NLRP3 inflammasome on vascular diseases.
- Author:
Zeng CAO
1
,
2
;
Yapei LI
1
,
3
;
Ruifang CHEN
4
,
5
;
Pingyu ZENG
4
,
5
Author Information
1. Department of Cardiology, Third Xiangya Hospital, Central South University
2. Center for Vascular Disease and Translational Medicine, Central South University.
3. . Center for Vascular Disease and Translational Medicine, Central South University, Changsha 410013, China.
4. Center for Vascular Disease and Translational Medicine, Central South University
5. . Medicine Experimental Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Caspase 1;
immunology;
metabolism;
Gene Expression Regulation;
genetics;
immunology;
Humans;
Inflammasomes;
immunology;
Inflammation;
complications;
genetics;
Interleukin-18;
genetics;
immunology;
Interleukin-1beta;
genetics;
immunology;
NLR Family, Pyrin Domain-Containing 3 Protein;
immunology;
Signal Transduction;
genetics;
immunology;
Vascular Diseases;
etiology;
genetics;
immunology
- From:
Journal of Central South University(Medical Sciences)
2016;41(11):1232-1236
- CountryChina
- Language:Chinese
-
Abstract:
The NLRP3 inflammasome, a protein complex belonging to the family of nucleotide-binding and oligomerization domain like receptors (NLRs), plays a vital role in the innate immune system. It promotes pro-caspase 1 cleavage into active caspase-1, which contributes to maturation and releases of IL-1β and IL-18 in response to the harmful signals and participates in the host immune response and sterile inflammation. Recently a large number of studies have shown that NLRP3 inflammasome closely relates to the pathogenesis of the vascular diseases. NLRP3 inflammasome, which involves in the sterile inflammation of the vascular wall, plays an important role in the pathogenesis of main, middle and small arteries.
