Expression of lactate dehydrogenase-5 in non-Hodgkin lymphoma and its clinical significance.
10.11817/j.issn.1672-7347.2016.12.010
- Author:
Fei DONG
1
;
Aixia SUI
2
;
Hongmei JING
1
Author Information
1. Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
2. Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Biomarkers, Tumor;
blood;
metabolism;
Female;
Humans;
Isoenzymes;
metabolism;
L-Lactate Dehydrogenase;
metabolism;
Lactate Dehydrogenase 5;
Lymphoma, B-Cell;
genetics;
Lymphoma, Large B-Cell, Diffuse;
genetics;
Lymphoma, Non-Hodgkin;
genetics;
Lymphoma, T-Cell;
genetics;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
genetics;
Prognosis;
Tumor Burden
- From:
Journal of Central South University(Medical Sciences)
2016;41(12):1312-1316
- CountryChina
- Language:Chinese
-
Abstract:
To determine expression of lactate dehydrogenase (LDH)-5 in non-Hodgkin lymphoma and its clinical significance.
Methods: LDH-5 levels and LDH levels in NHL patients were examined by agarose gel electrophoresis and enzymatic method (n=63), respectively. Positive rates of LDH-5 and LDH were statistically analyzed.
Results: The median age of NHL patients was 56(19-84) years old, including 36 males and 27 females. The positive numbers for LDH-5 and LDH in the initial treatment group (n=43) were significantly different (P<0.05). There was significant difference in 22 cases of diffuse large B cell lymphoma and in 9 cases of T cell lymphoma, whereas there was not significant difference in 12 cases of small B cell lymphoma (P>0.05). In 15 cases under the status of progress, the difference of LDH-5 and LDH expressions were not significant (P>0.05), whereas the difference in cases of small B cell lymphoma was significant (P<0.05).
Conclusion: LDH-5 can be used as an index for NHL to judge the tumor load and to predict the recurrence.
