Van Wyk-Grumbach syndrome: A case report and
literature review.
10.11817/j.issn.1672-7347.2016.12.020
- Author:
Ping JIN
1
;
Qin ZHANG
1
;
Zhaohui MO
1
;
Fan YANG
1
;
Yanhong XIE
1
Author Information
1. Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Congenital Hypothyroidism;
complications;
diagnosis;
etiology;
Diagnosis, Differential;
Diagnostic Errors;
Female;
Humans;
Hyperpituitarism;
Hyperplasia;
Menstruation Disturbances;
etiology;
Ovarian Cysts;
diagnosis;
etiology;
Ovary;
pathology;
Pituitary Gland;
pathology;
Puberty, Precocious;
diagnosis;
etiology;
Syndrome;
Thyroxine;
therapeutic use
- From:
Journal of Central South University(Medical Sciences)
2016;41(12):1366-1370
- CountryChina
- Language:Chinese
-
Abstract:
Van Wyk-Grumbach syndrome (VWGS) is a rare complication of prolonged untreated juvenile hypothyroidism characterized by precocious puberty and enlarged multicystic ovaries. A 13-year-old girl visited our outpatient clinic due to menstrual irregularities. She had precocious puberty, pituitary hyperplasia and multiple cystic ovaries in addition to clinical signs of severe congenital hypothyroidism. After the initiation of L-thyroxine therapy, the symptoms were alleviated in a short time. This rare syndrome is easy to be misdiagnosed as pituitary and ovarian tumor. High degree of suspicion and timely diagnosis can prevent unnecessary surgical procedures because the symptoms can be reversed with thyroid hormone supplementation.
