A case of light and heavy chain deposition disease.
10.11817/j.issn.1672-7347.2016.01.017
- Author:
Xian CHEN
1
;
Yueliang LONG
2
;
Xiaoping ZHU
1
;
Jun LI
1
;
Hong LIU
1
;
Shuguang YUAN
1
;
Letian ZHOU
1
Author Information
1. Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
2. Department of Nephrology, Anhua Hospital of Traditional Chinese Medicine, Anhua Hunan 413500, China.
- Publication Type:Case Reports
- MeSH:
Antibodies, Monoclonal;
adverse effects;
Basement Membrane;
physiopathology;
Biopsy;
Creatinine;
blood;
Heavy Chain Disease;
diagnosis;
drug therapy;
Humans;
Immunoglobulin Light Chains;
Kidney;
physiopathology;
Male;
Proteinuria
- From:
Journal of Central South University(Medical Sciences)
2016;41(1):109-112
- CountryChina
- Language:Chinese
-
Abstract:
Monoclonal immunoglobulin deposition disease is rare in medical practice. The light and heavy chain deposition disease is characterized by deposition of monoclonal antibodies in the basement of membrane. Kidney is the most frequently involved organ. There was a male patient diagnosed as light and heavy chain deposition disease in department of Nephrology of the Second Xiangya Hospital, Central South University by renal biopsy. After treatment by oral prednisone, melphalan and thalidomide, the patient's proteinuria and serum creatinine decreased. The retrospective analysis of this case provides a guide for doctors to understand the light and heavy chain deposition disease. Early diagnosis and treatment could improve the prognosis.
