Progress in studies on the role of β-catenin in regulating the self-renewal and pluripotency of embryonic stem cells.
10.11817/j.issn.1672-7347.2016.02.014
- Author:
Yang WANG
1
;
Xingxiang DUAN
1
;
Juan YU
2
;
Yi SUN
3
,
4
Author Information
1. Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410078, China.
2. National Engineering Research Center of Human Stem Cells, Changsha 410205, China.
3. Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410078
4. National Engineering Research Center of Human Stem Cells, Changsha 410205, China.
- Publication Type:Journal Article
- MeSH:
Blastocyst;
cytology;
Cell Differentiation;
Embryonic Stem Cells;
cytology;
Humans;
Wnt Signaling Pathway;
beta Catenin;
physiology
- From:
Journal of Central South University(Medical Sciences)
2016;41(2):206-211
- CountryChina
- Language:Chinese
-
Abstract:
Embryonic stem cells (ESCs) is one of the best cell types for regenerative medicine. It is derived from inner cell mass of the blastocyst stage and characterized by self-renewal and pluripotency, which are regulated by kinds of signal molecules, such as the Wnt/β-catenin signaling pathway. β-catenin is a multifunctional protein and plays a key role in Wnt/β-catenin signaling pathway. β-catenin involves self-renewal of ESCs and promotes the differentiation of ESCs into three primary germ layers in space and time. Elucidating the mechanisms of β-catenin in regulating the self-renewal and pluripotency of ESCs will pave the way to use it in research and application.
