Expression of miR-21 in peripheral blood serum and mononuclear cells in patients with chronic obstructive pulmonary disease and its clinical significance.
10.11817/j.issn.1672-7347.2016.03.003
- Author:
Lihua XIE
1
;
Fangying YANG
2
;
Shenghua SUN
3
Author Information
1. Department of Respiratory Disease, Third Xiangya Hospital, Central South University, Changsha 410013, China.
2. Department of Respiratory Disease, Fourth Hospital of Changsha, Changsha 410006, China.
3. Department of Respiratory Disease, Third Xiangya Hospital, Central South University, Changsha 410013.
- Publication Type:Journal Article
- MeSH:
Forced Expiratory Volume;
Humans;
Leukocytes, Mononuclear;
Lung;
MicroRNAs;
Pulmonary Disease, Chronic Obstructive;
Real-Time Polymerase Chain Reaction
- From:
Journal of Central South University(Medical Sciences)
2016;41(3):238-243
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore expression of miR-21 in peripheral blood serum and mononuclear cells of patients with chronic obstructive pulmonary disease (COPD), and to discuss the significance and underlying mechanisms.
METHODS:The subjects were divided into a healthy control group (n=41) and a COPD group (n=49). The miR-21 level was detected by quantitative real-time PCR. The correlations between miR-21 and lung function or forced expiratory volume in one second (FEV1) were analyzed.
RESULTS:The expression levels of miR-21 in the serum and mononuclear cells in the COPD group were significantly elevated compared with those in the healthy group (P<0.05). The expression of miR-21 was correlated with the lung function of COPD patients. The expression level of miR-21 in the COPD patients was positively correlated with FEV1.
CONCLUSION:The upregulation of miR-21 in peripheral blood serum and mononuclear cells of COPD patients may contribute to the pathogenesis of COPD and the severity of this disease.
