TRPM7 and tumor.
10.11817/j.issn.1672-7347.2016.03.017
- Author:
Min ZHAO
1
,
2
,
3
;
Chenhui LUO
1
,
2
,
4
,
5
;
Ying WANG
6
;
Jing WANG
6
Author Information
1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008
2. Institute of Clinical Pharmacology, Central South University
3. Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
4. Hunan Key Laboratory of Pharmacogenetics, Changsha 410078
5. Hunan Cancer Hospital, Changsha 410013, China.
6. Hunan Cancer Hospital, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Calcium;
Cell Differentiation;
Humans;
Neoplasms;
Protein-Serine-Threonine Kinases;
TRPM Cation Channels
- From:
Journal of Central South University(Medical Sciences)
2016;41(3):333-336
- CountryChina
- Language:Chinese
-
Abstract:
The transient receptor potential (TRP) family is a superfamily of cation channels located on the cell membrane. Transient receptor potential melastatin (TRPM) 7, a member of the TRPM subgroup of TRP channels, and was the most representative biofunctional membrane protein. It conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. It is capable of phosphorylating TRPM7 and other substrates. TRPM7 can mediate sensory transmission, regulate cellular Ca2+ and Mg2+ homeostasis and affect embryonic development. Abnormal expression and/or activity of the TRPM7 channel kinase is involved in a variety of diseases, particularly the development and progression of cancer. TRPM7 channel-kinase is essential for cellular processes, such as proliferation, survival, differentiation, growth, and migration.
