Expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia.
10.11817/j.issn.1672-7347.2016.07.008
- Author:
Hao LIU
1
;
Jing YANG
2
;
Lei ZHU
1
;
Yanfang LI
1
Author Information
1. Department of Gynaecology and Obstetrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
2. Department of Gynaecology and Obstetrics, People's Hospital of Kelamayi, Karamay Xinjiang 834000, China.
- Publication Type:Journal Article
- MeSH:
Autoantibodies;
Case-Control Studies;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Pre-Eclampsia;
Pregnancy;
Receptor, Muscarinic M2;
Severity of Illness Index
- From:
Journal of Central South University(Medical Sciences)
2016;41(7):707-710
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To test the expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia.
METHODS:A case-control study, including 78 patients with severe preeclampsia and 78 women with normal pregnancy in Department of Gynaecology and Obstetrics of Capital Medical University affiliated Beijing Chao-Yang Hospital from Jan, 2013 to Jan, 2015, were conducted, and 60 non-pregnant women were served as a control group. ELISA protocol was used to test serum autoantibody against the M2-muscarinic receptor. The clinical significance of the autoantibody against the M2-muscarinic receptor among women with severe preeclampsia was estimated.
RESULTS:Autoantibody against the M2-muscarinic receptor were positive in 32.1% (25/78) of patients with severe preeclampsia, in 10.3% (8/78, P<0.05) of normal pregnant women and in 8.3% (5/60, P<0.05) of non-pregnant controls. The concentration of creatine kinase in patients with severe preeclampsia and normal pregnant women were (101.49±142.75) and (57.94±31.64) U/L,
respectively. Mask difference exist between the severe preeclampsia group and the normal pregnancy group (P<0.05).
CONCLUSION:The expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia is elevated significantly, which is associated with severe preeclampsia. However, its etiological role needs further to be investigated.
