Effect of acitretin and methotrexate on treatment of
severe plaque psoriasis.
- Author:
Panpan LIU
1
;
Yehong KUANG
1
;
Jianglin ZHANG
1
;
Jie LI
1
;
Juan SU
1
;
Xiang CHEN
1
;
Wu ZHU
1
Author Information
- Publication Type:Journal Article
- MeSH: Acitretin; Humans; Methotrexate; Psoriasis
- From: Journal of Central South University(Medical Sciences) 2016;41(8):804-808
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate effects of acitretin and methotrexate on treatment of severe plaque psoriasis.
METHODS:A total of 54 patients were treated with either acitretin (32 patients; 30 mg per day) or methotrexate (22 patients; 15 mg per week) for 8 weeks. The therapeutic effects of the two drugs were evaluated according to the psoriasis area and severity index (PASI).
RESULTS:After 8 weeks of treatment, the score of PASI decreased in both the acitretin group and the methotrexate group (P<0.001). However, there was no significant differences neither in the percentage reduction in the PASI score nor in PASI response rate between the two groups (P>0.05).
CONCLUSION:Acitretin and methotrexate exert similar therapeutic effect in severe plaque psoriasis.
