Risk factors for early miscarriage among intrauterine singleton pregnancies after treatment with in vitro fertilization/intracytoplasmic sperm injection.
10.11817/j.issn.1672-7347.2016.08.007
- Author:
Hong ZENG
1
;
Nenghui LIU
1
;
Xiuli FAN
1
;
Muzhu CAI
1
;
Hebin XIE
2
Author Information
1. Reproductive Medical Center, Xiangya Hospital, Central South University, Changsha 410008, China.
2. Office of National High-Tech Project, Changsha Central Hospital, Changsha 410004, China.
- Publication Type:Journal Article
- MeSH:
Abortion, Spontaneous;
Case-Control Studies;
Female;
Fertilization in Vitro;
Humans;
Male;
Pregnancy;
Retrospective Studies;
Risk Factors;
Sperm Injections, Intracytoplasmic;
Spermatozoa
- From:
Journal of Central South University(Medical Sciences)
2016;41(8):815-820
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the risk factors associated with early miscarriage among intrauterine singleton pregnancies after treatment with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).
METHODS:A retrospective case-control study was performed on all singleton pregnancies underwent IVF/ICSI from January, 2013 to May, 2014, in Xiangya Hospital. Ninety-six early miscarriage patients served as a case group and 593 pregnancies with live birth served as a control group. We analyzed factors for early miscarriage after IVF/ICSI in two groups.
RESULTS:Multivariate logistic regression analysis demonstrated that the women age, miscarriage history, and sperm DAN fragmentation index (DFI) were the risk factors for early miscarriage (P<0.05).
CONCLUSION:Miscarriage after treatment with IVF/ICSI is affected by multiple factors. Women at elder age (>30 years old), women with a history of miscarriage or men with higher sperm DFI (≥15%) are the risk.
