Role of HIF-induced EMT in invasion and
metastasis of tumor.
10.11817/j.issn.1672-7347.2016.08.017
- Author:
Yang CHEN
1
;
Yan SHI
1
;
Guanghai DAI
1
Author Information
1. Department of Medical Oncology 2, Chinese PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Basic Helix-Loop-Helix Transcription Factors;
Epithelial-Mesenchymal Transition;
Humans;
Neoplasm Invasiveness;
Neoplasm Metastasis;
Neoplasms;
Transforming Growth Factor beta;
beta Catenin
- From:
Journal of Central South University(Medical Sciences)
2016;41(8):872-878
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia plays a vital role in tumor metabolism, proliferation, apoptosis, invasion and metastasis via hypoxia-inducible factor (HIF). Epithelial to mesenchymal transition (EMT) is a crucial process to metastasis, which could be triggered by hypoxia. EMT could be regulated by HIF via multiple pathways including TGF-β, Notch, and Wnt/β-catenin. It has been shown that anti-HIF drugs combined with anti-EMT therapies could be a promising strategy for tumor therapy.
