Clinical analysis of 45 patients with intracranial germinoma treated by radiotherapy.
10.3969/j.issn.1672-7347.2013.03.008
- Author:
Jidong HONG
1
;
Xia WANG
;
Yuping PENG
;
Longyun WANG
;
Lei HUO
;
Zaide HAN
;
Qingsong TU
Author Information
1. Department of Oncology,Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Antineoplastic Agents;
therapeutic use;
Brain Neoplasms;
drug therapy;
mortality;
radiotherapy;
Child;
Female;
Follow-Up Studies;
Germinoma;
drug therapy;
radiotherapy;
Humans;
Male;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2013;38(3):262-267
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To report the prospective efficacy of 45 patients intracranial germinoma treated by radiotherapy and discuss its treatment.
METHODS:From February 1998 to October 2007, a total of 45 intracranial germinoma patients were performed radiotherapy, including 15 combined chemotherapy in the Department of Oncology. Of them 23 were pathologically diagnosed while 22 cases were clinical diagnosed. Life table method showed the 5-year and 10-year survival rate.
RESULTS:Forty patients were followed-up. Most symptoms of the patients were significantly reduced or disappeared completely. The 5-year and 10-year survival rate of all patients were 84% and 74%.
CONCLUSION:Radiotherapy is the main treatment for intracranial germinoma. Craniospinal irradiation, whole brain irradiation and partial brain irradiation are the main treatments. Radiotherapy combined with chemotherapy, which can reduce the radiation range and dose will be the trend.
