Effects of ziprasidone and olanzapine on glucose and lipid metabolism in first-episode schizophrenia.
10.3969/j.issn.1672-7347.2013.04.005
- Author:
Ping SHAO
1
;
Jianjun OU
;
Renrong WU
;
Maosheng FANG
;
Honghui CHEN
;
Yi XU
;
Jingping ZHAO
Author Information
1. Department of Neurosis, Brain Hospital of Hunan Province, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Benzodiazepines;
adverse effects;
therapeutic use;
Blood Glucose;
drug effects;
Female;
Humans;
Lipid Metabolism;
drug effects;
Male;
Middle Aged;
Olanzapine;
Piperazines;
adverse effects;
therapeutic use;
Schizophrenia;
drug therapy;
Thiazoles;
adverse effects;
therapeutic use;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2013;38(4):365-369
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of ziprasidone and olanzapine on glucose and lipid metabolism in first-episode schizophrenia.
METHODS:A total of 260 schizophrenics were assigned randomly to receive ziprasidone or olanzapine for 6 weeks. The weight was measured at baseline, week 2, 4 and 6. Fasting blood glucose (FBS), fasting insulin, high-density lipoprotein (HDL), total-cholesterol (TC) and triglycerides (TG) were measured at baseline and the end of 6-week treatment. Low-density lipoprotein (LDL) was measured in some patients at baseline and the end of 6-week treatment. Body mass index (BMI) and insulin resistance index (IRI) were counted.
RESULTS:A total of 245 patients completed the trial, including 121 ziprasidone patients and 124 olanzapine patients. The average dose was 137.5 mg/d for ziprasidone and 19.5 mg/d for olanzapine. Patients treated with olanzapine had higher weight gain than those treated with ziprasidone [(4.55±3.37) kg vs (-0.83±2.05) kg, P<0.001]. After the treatment, FBS, fasting insulin, HDL, TC, TG, LDL and IRI levels were significantly increased in the olanzapine group (all P values<0.001 ). However, in the ziprasidone group, FBS decreased significantly and HDL and TG levels increased significantly after the 6-week treatment (all P values<0.05). The mean changes of FBS, fasting insulin, TC, TG, LDL and IRI were significantly different in the two groups (all P values<0.001).
CONCLUSION:Ziprasidone has less glucose and lipid metabolic effect for first-episode schizophrenia patients in short-term treatment. However, olanzapine induces weight gain and dysfunction of glucose and lipid metabolism significantly, which is associated with increased risk of complications. When the doctors choose antipsychotics in the clinic, they should consider the side effects of the medication.
