Application and evaluation of invasive prenatal diagnostic techniques and analysis of chromosomal karyotype.
10.3969/j.issn.1672-7347.2013.04.011
- Author:
Liqiong WANG
1
;
Xin WANG
;
Shaoling ZHANG
;
Zhongmin ZHOU
;
Fufan ZHU
;
Yiling DING
Author Information
1. Department of Obstetrics and Gynecology, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Abnormal Karyotype;
statistics & numerical data;
Adult;
Amniocentesis;
methods;
Cordocentesis;
adverse effects;
methods;
Evaluation Studies as Topic;
Female;
Humans;
Karyotyping;
methods;
Pregnancy;
Prenatal Diagnosis;
methods;
Retrospective Studies
- From:
Journal of Central South University(Medical Sciences)
2013;38(4):400-404
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the safety, effectiveness and complications of serial invasive prenatal diagnostic techniques, and to investigate the prenatal diagnosis indication as well as to analyze the abnormal chromosomal karyotype.
METHODS:We retrospectively studied all patients from March 2005 to May 2012 who received amniocentesis and cordocentesis in the prenatal diagnosis center of Second Xiangya Hospital. The indication of the procedure, successful rate and complications were evaluated, and 25 abnormal chromosome nuclear types were analyzed.
RESULTS:A total of 669 patients received invasive prenatal diagnosis from March 2005 to May 2012 in Second Xiangya Hospital: 598 received amniocentesis and 71 cordocentesis carried out. Compared with the cordocentesis group, the amniocentesis group had higher achievement ratio (91.54% vs 100%, P<0.05), lower spontaneous abortion rate (1.41% vs 0.33%, P<0.05), fewer abnormal karyotypes (11.27% vs 2.84%, P<0.05) and lower expenditure (880 yuan vs 800 yuan, P<0.05). Positive screening, advanced maternal age, and ultrasonography abnormality were the top 3 indications of amniocentesis and cordocentesis. We found 25 abnormal karyotypes, including 6 cases of trisomy 21, 4 sex chromosomal abnormalities, 7 autosomal balanced translocations, 1 marker chromosome, and 7 mosaics.
CONCLUSION:As a widely used invasive prenatal diagnosis, amniocentesis is safe and effective. The complications of cordocentesis are much higher than those of amniocentesis, which is not a proper routine procedure for prenatal diagnosis of abnormal karyotype. The analysis of karyotype not only can identify fetal chromosome abnormality, but also provide the scientific basis for pregnancy continuation, thus reducing the ratio of birth defect.
