Research progress of Th17 cells and glomerulonephritis.
10.3969/j.issn.1672-7347.2013.04.016
- Author:
Letian ZHOU
1
;
Fuyou LIU
Author Information
1. Second Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Glomerulonephritis;
immunology;
Humans;
Interleukin-17;
metabolism;
physiology;
Interleukin-23 Subunit p19;
physiology;
Interleukin-6;
physiology;
Nuclear Receptor Subfamily 1, Group F, Member 3;
physiology;
Th17 Cells;
immunology;
metabolism;
Transforming Growth Factor beta;
physiology
- From:
Journal of Central South University(Medical Sciences)
2013;38(4):432-436
- CountryChina
- Language:Chinese
-
Abstract:
T helper (Th) 17 cells are a kind of Th cell subset, and are distinct from the Th1 and Th2 cells and produce interleukin-17A (IL-17A, IL-17). Th17 cells have a mechanism of independent differentiation and developmental regulation. The differentiation and cytokine secretion of Th17 cells are regulated by TGF-β, IL-6, IL-23 and orphan nuclear receptor (RORγt). IL-17A induces pro-inflammatory cytokines and chemokines, mediating neutrophil recruitment. Increasing evidence implicated involvement of Th17 cells in anti-glomerular basement membrane disease, lupus nephritis and pauciimmune glomerulonephritis. In this review, we discussed the discovery of Th17 subset, its properties, its relationship with other Th subsets and involvement of Th17 cells in glomerulonephritis.
