Meta analysis of correlation of angiotensin-converting enzyme gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension in Chinese women.
10.3969/j.issn.1672-7347.2013.06.013
- Author:
Zhanzhan LI
1
;
Lizhang CHEN
;
Liya LIU
;
Jing XUE
;
Yang YANG
;
Yingyun HU
Author Information
1. Department of Epidemiology and Health Statistics, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Alleles;
Female;
Genetic Predisposition to Disease;
Humans;
Hypertension, Pregnancy-Induced;
genetics;
INDEL Mutation;
Peptidyl-Dipeptidase A;
genetics;
Polymorphism, Genetic;
Pregnancy;
Randomized Controlled Trials as Topic;
Risk Factors
- From:
Journal of Central South University(Medical Sciences)
2013;38(6):631-638
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association of the polymorphism of angiotensin-converting enzyme (ACE) gene and pregnancy-induced hypertension (PIH) in Chinese Women.
METHODS:We systematically searched CNKI, Wanfang database, VIP and PubMed from database construction to March 2012 to collect case-control studies. Stata 11.0 was used for meta analysis after evaluating the quality of studies and collecting the data. The association was assessed by odds ratio (OR) with 95% confidence intervals (CIs). Publication bias was analyzed by Begg's funnel plot and Egger's regression test.
RESULTS:We identified 11 case-control studies on association between ACE gene polymorphism and PIH, which included 806 PIH patients and 900 controls. Overall, significant association was found between ACE gene polymorphism and PIH risk [for D vs I: OR=2.73, 95% CI (1.64, 4.24), P<0.001; for DD+DI vs II: OR=3.11, 95% CI (1.98, 4.90), P<0.001; for DD vs II: OR=5.00, 95% CI (2.30,10.88), P<0.001; for DI vs II: OR=1.97, 95% CI(1.53, 2.53), P<0.001].
CONCLUSION:Chinese women with D allele gene deletion have a higher risk of suffering pregnancy induced hypertension syndrome.
