Expression of galectin-7 and S100A9 and development of cervical squamous carcinoma.
10.3969/j.issn.1672-7347.2013.09.004
- Author:
Hong ZHU
1
;
Li LIU
;
Huan LIU
;
Tiancong WU
;
Yue WU
;
Shan ZENG
;
Liang ZENG
Author Information
1. Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008,China.
- Publication Type:Journal Article
- MeSH:
Calgranulin B;
metabolism;
Carcinoma, Squamous Cell;
metabolism;
Cell Differentiation;
Cervical Intraepithelial Neoplasia;
metabolism;
Female;
Galectins;
metabolism;
Humans;
Lymphatic Metastasis;
Prognosis;
Proportional Hazards Models;
Survival Rate;
Uterine Cervical Neoplasms;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2013;38(9):888-895
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the correlation between the expression of galectin-7 and S100A9 with the development of cervical squamous carcinoma.
METHODS:Immunohistochemical SP staining was used to detect the expression of galectin-7 and S100A9 in 243 patients with cervical intraepithelial neoplasia (CIN) or cervical squamous carcinoma. The association of clinical data with galectin-7 and S100A9 expression was examined.
RESULTS:The expression of galectin-7 and S100A9 in CIN and cervical squamous carcinoma was significantly different (P<0.05). The positive rates of galectin-7 in normal cervical tissues, CIN I, CIN II, CIN III, and cervical squamous carcinoma were 56.7%, 41.9%, 32.0%, 27.3%, and 25.0%, respectively. Statistic analysis found significant difference between the normal cervical tissues and cervical squamous carcinoma (P<0.0045). The positive rates of S100A9 in CIN I, CIN II, CIN III, and cervical squamous carcinoma were 80.0%, 77.4%, 48.0%, 27.3%, and 20.2%. Statistic analysis showed significant difference between the normal tissues and CIN III, the normal cervical tissues and cervical squamous carcinoma, CIN I and CIN III, CIN I and cervical squamous carcinoma, CIN II and cervical squamous carcinoma (P<0.0045). A positive correlation was found between galectin-7 and S100A9 expression in CIN and cervical squamous carcinoma (rs=0.298, P<0.001). Expressions of both galectin-7 and S100A9 in cervical squamous carcinoma were associated with the clinical stage and lymph nodes (P<0.05), but not with patient's age and degree of differentiation (P>0.05). Expression of galectin-7 was associated with the survival rate of patients with cervical squamous carcinoma (P<0.05). Univariate analysis of Cox proportional hazards regression model revealed that the FIGO stage, lymph nodes metastasis, and the expression of galectin-7 were relevant to the 5 year survival rate of patients with cervical squamous carcinoma, which was confirmed by multiple analysis of Cox proportional hazards regression model.
CONCLUSION:Expression of galectin-7 and S100A9 is related with cervical the tumorigenesis of carcinoma, clinical stage, and lymph nodes of cervical squamous carcinoma. Galectin-7 is probably associated with the prognosis. The long-term survival of patients with cervical carcinoma may be associated with FIGO stage, lymph node metastasis, and the expression of galectin-7.
