Serum vitamin D levels in postmenopausal women with type 2 diabetes mellitus.
10.3969/j.issn.1672-7347.2013.10.012
- Author:
Lingjia LIU
1
,
2
,
3
,
4
;
Ying HU
;
Juanxia CHUI
;
Yuhang HU
;
Bichen WU
;
Xin SU
Author Information
1. Department of Endocrinology, Second Xiangya Hospital, Central South University
2. Diabetes Center, Central South University
3. Institute of Metabolism and Endocrinology, Central South University
4. Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Body Mass Index;
Calcitriol;
blood;
Case-Control Studies;
Diabetes Mellitus, Type 2;
blood;
Female;
Humans;
Postmenopause;
Prevalence;
Vitamin D Deficiency
- From:
Journal of Central South University(Medical Sciences)
2013;38(10):1051-1056
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the correlation between serum vitamin D levels and index of glucose and lipid metabolism in postmenopausal women with type 2 diabetes mellitus (T2DM).
METHODS:A total of 44 postmenopausal women with T2DM and 41 healthy postmenopausal women were matched with age, body mass index and menopausal duration. The serum vitamin D was detected by enzyme-linked immuno-sorbent assay (ELISA).
RESULTS:Compared with the control group, the level of 25(OH)D3 in postmenopausal women with T2DM was lower, with no statistical significance. Multiple regression analysis revealed that only BMI(bj'=-0.372, P<0.05) was independently related to 25(OH)D3 with statistical significance. The percentages of 25(OH)D3 deficiency in all subjects in the control group and in the T2DM group were 84.7%, 80.5%, and 88.6%, respectively. The 25(OH)D3 deficiency in the T2DM group was more prevalent than that in the control group, with no statistical difference (P=0.372). The binary logistic regression analysis showed the serum 25(OH)D3 level was not related to the risk of diabetes.
CONCLUSION:Compared with the control group, a lower 25(OH)D3 level and a higher rate of 25(OH)D3 deficiency is found in T2DM subjects. When rectified by BMI, these is no significant difference. In postmenopausal women, hypovitaminosis D is associated with obesity and dyslipidemia, but not with the risk of T2DM.
