Association between CD24 polymorphism and genetic susceptibility to breast cancer: a case-control study.
10.3969/j.issn.1672-7347.2013.11.007
- Author:
Xin ZHOU
1
;
Yong CAO
;
Jie LUO
;
Xiaohua ZENG
Author Information
1. Department of Breast Surgery, Chongqing Cancer Institute, Chongqing 400030, China.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
Breast Neoplasms;
genetics;
CD24 Antigen;
genetics;
Case-Control Studies;
China;
Female;
Genetic Predisposition to Disease;
Genotype;
Humans;
Polymorphism, Single Nucleotide
- From:
Journal of Central South University(Medical Sciences)
2013;38(11):1122-1129
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the association between CD24 polymorphism and genetic susceptibility to breast cancer in Chongqing women of Han nationality.
METHODS:In the case-control study, single nucleotide polymorphism of CD24 (rs3838646 and rs52812045) was genotyped by Sequenom MassArray®iPLEX GOLD System in 170 patients with breast cancer and 178 healthy controls. Data were analyzed via t test, Chi-square test, and logistic regression analysis.
RESULTS:The distribution of CD24 rs3838646 genotype and allelotype had no significant difference between the patients with breast cancer and healthy controls (χ2=3.54, P=0.17; χ2=2.29, P=0.13). Stratified by menstruation status, premenopausal individuals carrying CD24 rs3838646 Del allele significantly reduced the risk (OR=0.51, 95% CI 0.26-1.00, P=0.0485) of breast cancer compared with the individuals carrying CD24 CA/CA genotype. The distribution of CD24 rs52812045 genotypes and allelotypes had no significant difference between the patients with breast cancer and healthy controls (χ2=5.37, P=0.07; χ2=3.05, P=0.08). Compared with C/C homozygotes, CD24 rs52812045 T/T homozygotes had a significantly reduced risk (OR=0.47, 95% CI 0.23-0.95; P=0.04) for breast cancer.
CONCLUSION:CD24 polymorphism may be a marker for susceptibility to breast cancer in Han population in southwestern China. CD24 polymorphisms may be associated with a reduced risk of breast cancer in Chinese population. Further studies are needed to confirm these findings.
