Impact of Down syndrome on the surgical treatment of congenital heart defects.
10.3969/j.issn.1672-7347.2012.07.008
- Author:
Weizhi ZHANG
1
;
Yifeng YANG
;
Can HUANG
;
Tianli ZHAO
Author Information
1. Department of Cardiothoracic Surgery, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Child;
Child, Preschool;
Down Syndrome;
complications;
Female;
Heart Defects, Congenital;
complications;
mortality;
surgery;
Heart Septal Defects, Ventricular;
complications;
mortality;
surgery;
Humans;
Infant;
Male;
Postoperative Complications;
etiology;
Retrospective Studies;
Survival Analysis;
Treatment Outcome
- From:
Journal of Central South University(Medical Sciences)
2012;37(7):695-698
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the impact of Down syndrome (DS) on surgical management in patients with congenital heart defects (CHD).
METHODS:We retrospectively analyzed the clinical data from 35 children with DS and CHD, who underwent cardiac surgery between 2004 and 2009. The data on surgical mortality, complications and follow-up results are emphasized.
RESULTS:All of the patients underwent primary repair. One child (2.9%) with DS and complete atrioventricular septal defect (CAVSD) died early postoperatively because of pulmonary hypertension. Two patients (5.7%) had low cardiac output syndrome, and 15 (42.9%) suffered pulmonary complications. III degree atrioventricular block (AVB) occurred in 4 patients (11.5%). Thirty children who were followed up 10 months to 6 years [(3.8±1.1) years] are in NYHA class I or II. There were no reoperations or later death.
CONCLUSION:CHD in DS children can be repaired with a low risk of mortality, although a high incidence of severe infections and III degree AVB can result in a complicated postoperative course. The results of mid-term follow up are satisfactory.
